In order to understand CBD tolerance, and how to avoid it, it helps to know what is being avoided.
It’s great to throw a word like ‘tolerance’ around, and its basic meaning is understood by most, even if the functional understanding of how it happens is not.
Sure, we know that the body essentially acclimates to the substance, thereby not responding to it in the same way, but what does this mean?
In terms of pharmacodynamics (how a substance effects the body), tolerance occurs at the cellular level, when a substance is repeatedly used, leading to less response by the cell.
Most of the time this is from a large amount of a substance consistently binding to the same receptor until the receptor becomes desensitized to the substance.
Another form of pharmacodynamic tolerance is when the number of receptors is reduced, which means a change in firing rate and action potential.
Tolerance happens in another way as well, pharmacokinetic tolerance, which explains how the body effects the substance.
Pharmacokinetics deals with how the substance is treated by the body through absorption, distribution, metabolism, and excretion.
This kind of tolerance refers to the decreased amount of the substance that’s capable of reaching reactor sites. This is often caused by increased enzyme action to break down the substance before it can do what its supposed to.
What about CBD tolerance?
The study Cannabidiol (CBD) Tolerance in Children and Adults With Treatment-resistant Epilepsy was published in 2021, and gives a view of the subject.
The study lasted three years and looked at tolerance among 92 treatment-resistant epileptic patients.
In this study, tolerance was defined as either the need to increase dosage because of reduced efficacy by at least 30%, or with a 30% or more increase in symptoms with at least three months treatment, and no increase in medication.
Tolerance to the CBD was found in only 25% of the population, starting at approximately 7.3 months.
How to Avoid CBD Tolerance?
The main way of avoiding tolerance, or lessening it when if you happen to be one of the 25%, is simply to take a break.
It was found that after a break of just two days CBD receptors become more active again.
Conclusion
A good rule of thumb, is if you find yourself not feeling all the effects, take a few days off, let your tolerance lower and start taking it again.
The US FDA and Australian TGA do not allow any claims about what CBD oil can do or may do for you. But we can pass along that there are thousands of people worldwide who use CBD oil regularly to relieve the symptoms of many health and you can find out for yourself by searching online for “CBD oil and your condition”. But the only way you’ll know for sure if it will help you is to try it. (If you need further advice, your doctor or medical practitioner might be able to help.)
Again, we cannot administer medical advice. But, we can report that many toddlers are taking CBD oil daily for many of the same medical conditions that teens and adults are using it for. As well, we are aware of numerous pets who take CBD oil daily without any ill effects.
When using the drops, the best way to take them is sublingually. And, the easiest way to do this is by setting a spoon on a counter and dripping the desired number of drops into the spoon. Then, by putting the spoon into your mouth, put the liquid under your tongue for about 90 seconds, then swallow. For those who prefer to take their drops in a drink, this can be done. However, because the stomach acids work very quickly to break down the cannabinoids, it is only partially effective. When taking in drinks/foods, we recommend taking approximately twice as much as if you’re taking it sublingually.
There is no scientific data that says any particular amount is optimal and, by FDA guidelines, no one can say that any amount of CBD will cure, help or treat any health condition.
But, here’s what can be shared. Consider two things: your weight and the severity of your condition. The bigger you are, the more CBD one typically has to take. And, the more severe the situation, the more CBD one typically has to take.
The following chart may help in determining a “STARTING POINT” of how much you might want to take per day initially. Again, there is no scientific statement as to what is right, the following is a “best practices” guideline put together for your help:
The approach we recommend is to begin taking a particular amount twice a day for the first 3-4 days to build it up in your system and so you can truly see what it’s doing. After this amount of time, increase or decrease the amount you’re taking based on the results you’re seeing.
Increasing the dose will not always give a better result. An animal study published back in 1990 found that low to moderate CBD doses reduced anxiety, but CBD’s anti-anxiety effect disappeared at higher doses. Importantly, the authors note an inverted-U response to CBD. Out of the four doses tested, the lowest dose had a moderate anti-anxiety effect, the second-lowest dose had the greatest anti-anxiety effect, the third dose had a moderate effect, and the highest dose had no effect.
Here are some examples of dosing calculations:
1) If you want to take 15mg per day and your product has 0.83mg per drop, you would take 18 drops per day or 9 drops morning and night. (18 x 0.83 = 15mg)
2) If you want to take 15mg per day and your product has 2.5mg per drop, you would take 6 drops per day or 3 drops morning and night. (6 x 2.5 = 15mg)
3) If you want to take 15mg per day and your product has 4mg per drop, you would take 4 drops per day or 2 drops morning and night. (4 x 4 = 16mg)
There’s no definitive answer to this question.
Most people tend to work out their daily dose and then split it into two amounts and take one morning, one night.
However, CBD is biphasic which means that at smaller doses it can be a bit stimulating and at higher doses somewhat sedating.
So, some people who use it for sleep, prefer to take the whole dose night for the sedating effect.
Cannabidiol (CBD) is a naturally occurring constituent of industrial hemp/cannabis. It is the most abundant non-psychoactive cannabinoid found in cannabis, and is being scientifically investigated for various reasons.
CBD oil is a cannabis oil (whether derived from marijuana or industrial hemp, as the word cannabis is the Latin genus name for both) that has significant amounts of cannabidiol (CBD) contained within it. CBD oil is derived from industrial hemp, also often called CBD-rich hemp oil, hemp derived CBD oil, CBD-rich cannabis oil, or plainly “hemp extracts” since it typically contains much more than just CBD. Again, cannabis doesn’t mean marijuana, but is the genus name, and general umbrella term which all forms of marijuana and hemp fall under.
When taking enough, it generally only takes about 20-30 minutes for it become effective. Most people when first starting out, do not know what to expect and often overlook that it is beginning to help their condition. Since there is no “high” to report, most people don’t know that it is doing anything. Only after a while do they realize that any pain they may have had is no longer there or not as intense. The feeling is so subtle that usually all that is able to be identified is a subtle calming. After several uses, many people have reported that they now notice it “taking the edge” off minutes after administering. But, for most newcomers, they expect a huge change and it’s just not like that, unless it’s being used for pain management. A gentle release of the pain is usually fairly noticeable when taking these products in proper amounts.
CBD oil is considered generally safe, so there shouldn’t be any significant side effects, but we can’t rule them out as it really depends on how your body tolerates and adapts to it. We recommend to consult your physician before using CBD oil.
Possibly. CBD inhibits the cytochrome P450 enzyme, which is involved in metabolizing many drugs. Compounds in grapefruit inhibit the same enzyme group, which is why physicians advise patients not to eat grapefruit shortly before or after taking a medication. By inhibiting cytochrome P450, CBD can either reduce or increase the effects of other drugs. In some situations, it may be advisable for a physician to monitor a patient’s blood levels of other medications while taking CBD.
THC is the compound in cannabis that makes one “high”. The amount of THC in Canntica CBD oil is zero so it is impossible to get “high” from it. Also, CBD Oil is totally non-addictive. In fact, it has been shown to help people kick drug, cigarette and alcohol addictions.
It can be both! It is biphasic which means in smaller doses it tends to be somewhat stimulating (although not like caffeine) but has a sedating effect in higher doses eg, if used to help sleep conditions.
CBD may help to decrease appetite. A study conducted on mice by researchers at the NIH’s National Institute on Alcohol Abuse and Alcoholism seems to show that obesity can be caused by an imbalance of cannabinoids in the body and CBD may be a promising treatment to correct the problem.
We are not doctors and we are not knowledgeable about your particular health condition, so you have to get medical advice from your practitioner. However, what we can say is that typically, its virtually impossible to take too much. We use the following analogy: Can you eat too much spinach? Well, the answer is yes, you can. But, you’d have to eat such an unimaginable amount that it’s not realistic to think you could truly eat too much spinach. The same holds true for CBD oil. It’s not realistic to think you could take too much, but of course, at some level it would be possible. (Again, please consult your physician regarding your specific situation).
No. CBD oil such as Canntica is not addictive, nor can it make an individual feel “stoned.”
Marijuana is well-known as an addictive. However, confusion often surrounds hemp and cannabidiol (CBD), which are related to marijuana but do not contain the psychoactive component that characterizes marijuana.
In fact, CBD actually counteracts the psychoactive influence of THC and has demonstrated anti-psychotic effects in schizophrenia patients.
The concentration of THC in marijuana is high enough to potentially cause addiction.
However, Canntica contains zero THC and there can’t create an addiction.
Individuals who wish to treat medical ailments or symptoms with herbal medicine often want the benefits of using CBD such as Canntica.
These drug tests are looking solely for THC, the component in cannabis that gets you ‘high’. Since Canntica contains zero THC, it shouldn’t be picked up in a drug test. Having said that, if you take very high doses of CBD (over 1000mg per day!) there is the possibility of a false positive in a urine drug test (which aren’t very accurate) but once the confirming blood test is done, the result should come back as negative.
Scientifically, industrial hemp and marijuana are the same plant, with a genus and species name of cannabis sativa. They have a drastically different genetic profile though. Industrial hemp is always a strain of cannabis sativa, while marijuana can be cannabis sativa, cannabis indica, or cannabis ruderalis. The major difference is how industrial hemp has been bred compared to a marijuana form of cannabis sativa.
Typically speaking, industrial hemp is very fibrous, with long, strong stalks, and barely has any flowering buds, while a marijuana strain of cannabis sativa will be smaller, bushier, and full of flowering buds. However, newer industrial hemp varieties in the USA are being bred to have more flowers and higher yields of cannabinoids and terpenes.
99% of the time marijuana has a high amount of THC and only a very low amount of CBD. Hemp, on the other hand, naturally has a very high amount of CBD in most instances, and only a trace amount of THC, the psycho-active component of cannabis that gets you “high”.
Fortunately, the cannabinoid profile of hemp is ideal for people looking for benefits from cannabis without the ‘high.’ Hemp is used for making herbal supplements, food, fibre, rope, paper, bricks, oil, natural plastic, and so much more, whereas marijuana is usually used just recreationally, spiritually, and medicinally. The term cannabis oil can refer to either a marijuana or hemp derived oil, since marijuana and hemp are two different forms of cannabis.
Hemp seed oil can be made from the seeds of any plant in the cannabis family, but is primarily derived from hemp. The seeds themselves contain as much as 50% of their weight in oil, which is easily extracted. For the most part, these seeds are used for their nutritional value rather than for profound health benefits.
The seeds themselves contain very little CBD—not nearly enough to take advantage of its health inducing properties. Likewise, the seeds only contain trace amounts of THC, making them useless for anyone looking to get high. And unlike CBD oil, hemp seed oil has a strong nutritional value, as it is high in polyunsaturated fats like Omega-6 and Omega-3 fatty acids, as well as Vitamin E.
Because of this profile and its low amount of saturated fats in comparison to other oils, hemp seed oil has found a spot in many kitchens around the world. It can have a nutty to grassy flavour depending on how it’s refined, and high quality brands can be used for salad dressing and cooking.
The underlying difference between the two products is that one (CBD oil) is medicinal and the other (hemp seed oil) is much cheaper and an ingredient used for both cooking and manufacturing. Knowing the difference ensures that patients and health enthusiasts are getting the best possible product for their specific needs.
Generally, CBD oil can be stored at room temperature, out of direct sunlight although refrigerated or frozen is best, especially once the bottle has been opened. The shelf life for Canntica is two years if refrigerated or frozen.
CBD oil legal in all 50 US states and over 50 countries worldwide. It does not require any prescription nor medical card in the United States. In Australia, CBD oil is currently only available locally by prescription and is therefore unavailable to most Australians in need of this life-changing product. However, feedback from our Australian clients indicates that our small bottles of CBD oil for personal use are being delivered and we guarantee receipt of all orders. If you are in another country, please check your local laws.
The answer to these questions lies in the fact that there are many steps and much plant material required to produce the end product. First, a fairly substantial amount of hemp has to be grown, which takes months, to produce enough seeds and stalk to produce a very small amount of hemp extract. Then, the extract has to be extensively tested to ensure its compound make up and its purity. The extract is then formulated into CBD oil.
The best way to compare prices is to break each product down to a “cost per milligram of CBD”. By doing this, you can then start to compare the prices of the products.
Also, as a general rule of thumb, the most common amount used is 15mg per day for general health maintenance and on this basis, a 5000mg bottle would last almost a year and cost less than $1.40 per day which is very affordable for most people.
Canntica is sourced from the ONLY large scale, fully vertically integrated, US based, 100% federally legal producer and distributor of the highest quality medicinal hemp in the United States.
What sets Canntica apart from “hemp oil hustlers”, begins with our proprietary medicinal cannabis strain. Our proprietary strain is a hybrid AC/DC x Cannatonic x (another naturally high CBD strain), all of which are known for their medicinal value. The cross-breeding of this naturally high CBD/low THC strain took place over a seven year period, and was done in order to reduce the amount of naturally occurring THC down to a level that classified it as “industrial hemp” (less than .3%) .
While everyone else was cross-breeding their strains to increase the level of THC, we had the foresight to do the complete opposite! Canntica is a zero THC full-spectrum oil. We achieve this through a process that allows us to identify the naturally occurring THC and separate it out completely, instantly, while leaving intact the other synergistic components of the oil.
NOT ALL HEMP IS CREATED EQUAL …
Industrial hemp is genetically inferior to medicinal hemp, yet it is defined the same way by the regulatory agencies. Many brands/companies/legal counsel who still believe that hemp-derived CBD must come from overseas to be “fully legal” are not taking into consideration the 2014 US Farm Bill section 7606 which created for the first time since 1937, a Federally legal pathway to growing “industrial hemp” once again on American soil. Our supplier conforms entirely to section 7606 of the 2014 Farm Bill and our “medicinal hemp” strain is registered with the Colorado State Department of Agriculture as “industrial hemp”.
As demand for CBD continues to grow, so too will the synthetic forms of CBD crystalline isolate coming out of China and Eastern Europe. CBD buyers need to be cautious when purchasing CBD from overseas, as much of it contains heavy metals, toxins, and/or mysterious chemicals. True quality control can only be guaranteed if all aspects of the supply chain and manufacturing is vertically-integrated.
We are supplied from the largest, most reliable, most consistent, and most dependable source of the highest grade “medicinal hemp” naturally rich in CBD, along with a full spectrum of cannabinoids and terpenes all working synergistically to provide true medical benefits. Industrial hemp CBD oil from China and Europe, is being flooded into the US market and touted as an effective CBD product, but it is not.
This is troubling. Almost all hemp is a “bioaccumulator” ie, it has an extraordinary ability to absorb toxins from polluted soils—it’s a natural soil remediator. After the 1988 Chernobyl nuclear reactor meltdown, hemp was planted around the contaminated disaster site for exactly that reason.
Oils extracted from plants grown near soils contaminated by pesticides or industrial effluents may contain those impurities in concentrated amounts. In today’s CBD market, manufacturers are under no obligation to tell consumers where their hemp was grown or to test it for contaminants.
The good news is that the special strain of medicinal cannabis used to produce Canntica is NOT a bioaccumulator!
If you are looking for a reliable, dependable, and consistent source of the highest quality, Federally legal, non-GMO, American Made “medicinal hemp” CBD using organic farming methods, then Canntica is your best choice.
Here’s a link to our quality control lab test results
Simply put, industrial hemp is virtually all the hemp grown in the world today. Non-industrial hemp would be marijuana. Because of all the cross breeding, there is little delineation between what is a hemp plant and what is a marijuana plant. Industrial hemp is the cannabis plant that is exceptionally low in THC. What we call “Pharmaceutical Grade Hemp” is Industrial Hemp that has been specifically bred to have high levels of cannabinoids and is meticulously grown to ensure exacting and high standards.
Let’s first point out that taste is highly subjective. So, what tastes good to one, may not taste good to another. Secondly, let’s point out that people don’t typically take CBD oil because they’re hungry and they want some good tasting food. They’re taking it for some degree of well-being and most people who have had their life changed by CBD Oil couldn’t care less how it tastes.
Now, on to the flavour. At the base of the product is a plant extract from hemp. And, just like most herbal extracts and bitters, this extract doesn’t taste so good, generally speaking. This is why many manufacturers have infused the sticky, gooey extract into bottles of carrier oils for drops. This reformulated version of CBD oil typically tastes better than the straight extract. So, in comparison, yes, these products taste good when compared to the straight extract. But, they all will still have some degree of “plant” or hempiness to them.
The main ingredient is pure cannabidiol (CBD) oil plus carrier oil MCT (Brain Octane Oil), a very healthy extract of coconut oil. These are used to adjust the content of CBD oil to the required concentration. There are no other ingredients.
