There’s no definitive answer to this question.

Most people tend to work out their daily dose and then split it into two amounts and take one morning, one night.

However, CBD is biphasic which means that at smaller doses it can be a bit stimulating and at higher doses somewhat sedating.

So, some people who use it for sleep, prefer to take the whole dose night for the sedating effect.

In order to understand CBD tolerance, and how to avoid it, it helps to know what is being avoided.

It’s great to throw a word like ‘tolerance’ around, and its basic meaning is understood by most, even if the functional understanding of how it happens is not.

Sure, we know that the body essentially acclimates to the substance, thereby not responding to it in the same way, but what does this mean?

In terms of pharmacodynamics (how a substance effects the body), tolerance occurs at the cellular level, when a substance is repeatedly used, leading to less response by the cell.

Most of the time this is from a large amount of a substance consistently binding to the same receptor until the receptor becomes desensitized to the substance.

Another form of pharmacodynamic tolerance is when the number of receptors is reduced, which means a change in firing rate and action potential.

Tolerance happens in another way as well, pharmacokinetic tolerance, which explains how the body effects the substance.

Pharmacokinetics deals with how the substance is treated by the body through absorption, distribution, metabolism, and excretion.

This kind of tolerance refers to the decreased amount of the substance that’s capable of reaching reactor sites. This is often caused by increased enzyme action to break down the substance before it can do what its supposed to.

What about CBD tolerance?

The study Cannabidiol (CBD) Tolerance in Children and Adults With Treatment-resistant Epilepsy was published in 2021, and gives a view of the subject.

The study lasted three years and looked at tolerance among 92 treatment-resistant epileptic patients.

In this study, tolerance was defined as either the need to increase dosage because of reduced efficacy by at least 30%, or with a 30% or more increase in symptoms with at least three months treatment, and no increase in medication.

Tolerance to the CBD was found in only 25% of the population, starting at approximately 7.3 months. 

How to Avoid CBD Tolerance?

 The main way of avoiding tolerance, or lessening it when if you happen to be one of the 25%, is simply to take a break.

It was found that after a break of just two days CBD receptors become more active again.

Conclusion

A good rule of thumb, is if you find yourself not feeling all the effects, take a few days off, let your tolerance lower and start taking it again. 

No, because it’s super-easy and convenient to make your own at home using our powerful and cost-effective CBD oil.

Here are the instructions:

Make sure to note three main aspects, and you can enjoy a DIY version within minutes.

1. Choosing Your Base

When making a base, there are many different ingredients to choose from, such as:

Shea butter
Cocoa butter
Coconut oil
Jojoba oil
Olive oil
Wax
Beeswax
Or any store-bought lotions.

Each one comes with its own benefits and will provide a different consistency. Beeswax, for example, is more frequently used to create a harder salve, as opposed to a softer lotion.

A salve will be an ideal choice if you intend on applying the topical to a small, contained area.

However, a lotion will be easier to spread across a larger area.

You can combine however many ingredients you feel are necessary to make you base. For example, coconut oil and beeswax may provide a balanced consistency that also massages the skin.

Alternatively, if you’re on a budget, simply incorporating your chosen CBD oil with a store-bought lotion will serve your needs properly.

Be sure to check the ingredients list, however, and ensure your branded lotion has a low water content. Water and oil don’t mix, after all, and this can lead to a topical that doesn’t spread evenly.

2. Choosing your CBD Oil

When making a topical, you’re going to use anywhere from 300 to 600 milligrams of cannabidiol oil so you will want to choose a concentrated oil suitable for this purpose.

3. Measure Properly

Measuring becomes extremely important, as you want to balance the amount of base with the amount of CBD oil, according to how much is needed each time.

When making a salve, you’ll be using less total ingredients than with a lotion. This is because salves are more condensed and deliver focused results, so you can incorporate less beeswax but the same amount of CBD oil.

If you decide to make your own salve, add the CBD oil before taking it off the heat. If you decided to buy a pre-made salve, remove it from its container and heat it either on low in the microwave or in a pot on the stove at low heat.

Add 400mg of CBD oil for every 60ml of salve.

We would recommend using either the Canntica 2500mg or the 5000mg best value for this because they are the most concentrated at 4mg per drop.

If you use either of these products, you’ll be using 100 drops (4 x 100 = 400mg) for every 60ml of salve.

For a lotion topical, you’ll have more to use, but you’ll need a greater amount to get the same affect.

Since lotion is already easy to mix, simply add 600mg of CBD oil for every one cup of lotion and stir until completely dispersed into the lotion.

Again, we would recommend using either the Canntica 2500mg or the 5000mg best value for this because they are the most concentrated at 4mg per drop.

If you use either of these products, you’ll be using 150 drops (4 x 150 = 600mg) for every one cup of lotion.

If you decide later that your topical is too strong or too weak, you can add more base or CBD oil to it as needed. Salves will need to be warmed up before adding more CBD oil, as they tend to harden and will resist the oil.

Now you can use CBD oil in two ways: systemically by placing drops under the tongue and topically via your salve or lotion.